Annual report pursuant to Section 13 and 15(d)

Annual report pursuant to Section 13 and 15(d)

Stock Options, Stock Purchase Plan and Warrants - Additional Information (Detail)

v3.6.0.2
Stock Options, Stock Purchase Plan and Warrants - Additional Information (Detail) - USD ($)
12 Months Ended
Jan. 09, 2012
Jan. 01, 2007
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
May 03, 2010
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Amended Plan expiration date     Oct. 15, 2025        
Common stock reserved and available for issuance under the Amended Plan     12,500,000        
Stock option outstanding     5,136,110 5,326,505 4,012,096 5,725,298  
Stock option to purchase     2,617,526 1,819,000 760,500    
Shares were available for future option and stock awards under the Amended Plan     1,670,205 4,081,940      
Aggregate intrinsic value of all stock options outstanding and expected to vest     $ 14,500,000        
Aggregate intrinsic value of currently exercisable stock options     $ 5,300,000        
Common stock closing price     $ 8.57        
Total number of in the money options outstanding and exercisable     1,100,000        
Total intrinsic value of options exercised     $ 15,003,000 $ 2,470,000 $ 8,882,000    
Total cash proceeds received from the exercise of stock options     4,179,000 714,000 1,807,000    
Total fair value of options granted     6,493,000 3,347,000 1,139,000    
Total fair value of option shares vested     2,165,000 $ 871,000 $ 540,000    
Unrecognized stock-based compensation cost     $ 5,100,000        
Unrecognized cost is expected to be recognized over a weighted-average period     1 year 4 months 24 days        
Shares issued under ESPP     98,672 73,958 90,285    
Common stock warrants issued to the Consultant (Steven Jones)             450,000
Class of Warrant or Right, Exercise Price of Warrants or Rights     $ 1.50       $ 1.50
Number outstanding     450,000        
Issued     May 03, 2010        
Expired     May 02, 2017        
Albitar Warrants [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Expiration date     Jan. 09, 2017        
Warrant [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Stock compensation expense     $ 0 $ 0 $ 51,000    
Warrants granted 200,000   0 0 0    
Weighted average exercise price, granted $ 1.43   $ 0 $ 0 $ 0    
Employee Stock Purchase Plan [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Limited payroll deductions a discount   5.00%          
Stock Options [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Stock compensation expense     $ 4,978,000 $ 2,889,000 $ 511,000    
Chief Executive Officer [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Stock option to purchase     200,000 800,000      
Minimum [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Options expiry period     5 years        
Stock option term     3 years        
Maximum [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Options expiry period     10 years        
Stock option term     4 years