Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS??? EQUITY

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common Stock	Additional Paid-In Capital	Additional Paid-In Capital Cumulative Effect, Period of Adoption, Adjustment	Accumulated Other Comprehensive (Loss) Income	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
Beginning balance (in shares) at Dec. 31, 2019			104,781,236
Beginning balance at Dec. 31, 2019	$ 507,408		$ 105	$ 520,278		$ (1,618)	$ (11,357)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Common stock issuance ESPP plan (in shares)	138,309		138,309
Common stock issuance ESPP Plan	$ 3,579			3,579
Issuance of restricted stock, net of forfeitures (in shares)			97,478
Issuance of restricted stock, net of forfeitures	$ (1,276)			(1,276)
Issuance of common stock for stock options (in shares)	2,310,934		2,306,951
Issuance of common stock for stock options	$ 18,275		$ 2	18,273
Issuance of common stock - public offering, net of underwriting discounts (in shares)			4,751,500
Issuance of common stock - public offering, net of underwriting discounts	127,293		$ 5	127,288
Stock issuance fees and expenses	(268)			(268)
ESPP expense	875			875
Stock-based compensation expense - options and restricted stock	9,337			9,337
Equity component of Convertible Senior Notes due 2025	30,912			30,912
Tax liability related to Convertible Senior Notes due 2025	(7,504)			(7,504)
Convertible note debt issuance costs	(137)			(137)
Loss on effective cash flow hedge, net	(1,000)					(1,000)
Cash flow hedge termination reclassified to earnings	2,661					2,661
Net unrealized loss on marketable securities, net of tax	(33)					(33)
Net Income (Loss)	4,172						4,172
Ending balance (in shares) at Dec. 31, 2020			112,075,474
Ending balance at Dec. 31, 2020	694,294	$ (22,576)	$ 112	701,357	$ (23,271)	10	(7,185)	$ 695
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Premiums paid for capped call confirmations	$ (29,291)			(29,291)
Common stock issuance ESPP plan (in shares)	112,094		112,094
Common stock issuance ESPP Plan	$ 4,360			4,360
Issuance of restricted stock, net of forfeitures (in shares)			811,335
Issuance of restricted stock, net of forfeitures	$ (2,817)		$ 1	(2,818)
Issuance of common stock for stock options (in shares)	1,372,564		1,372,564
Issuance of common stock for stock options	$ 13,678		$ 1	13,677
Issuance of common stock - private placement, net of private placement fees (in shares)			4,444,445
Issuance of common stock - private placement, net of private placement fees	189,863		$ 4	189,859
Issuance of common stock - public offering, net of underwriting discounts (in shares)			4,693,876
Issuance of common stock - public offering, net of underwriting discounts	218,500		$ 5	218,495
Issuance of common stock for acquisition (in shares)			597,712
Issuance of common stock for acquisition	29,175		$ 1	29,174
Stock issuance fees and expenses	(372)			(372)
ESPP expense	1,052			1,052
Stock-based compensation expense - options and restricted stock	21,406			21,406
Net unrealized loss on marketable securities, net of tax	(648)					(648)
Net Income (Loss)	(8,347)						(8,347)
Ending balance (in shares) at Dec. 31, 2021			124,107,500
Ending balance at Dec. 31, 2021	$ 1,108,277		$ 124	1,123,628		(638)	(14,837)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Common stock issuance ESPP plan (in shares)	415,450		415,450
Common stock issuance ESPP Plan	$ 3,787			3,787
Issuance of restricted stock, net of forfeitures (in shares)			1,446,783
Issuance of restricted stock, net of forfeitures	$ (1,577)		$ 2	(1,579)
Issuance of common stock for stock options (in shares)	949,259		944,259
Issuance of common stock for stock options	$ 10,378		$ 1	10,377
Stock issuance fees and expenses	(3)			(3)
ESPP expense	1,040			1,040
Stock-based compensation expense - options and restricted stock	23,632			23,632
Net unrealized loss on marketable securities, net of tax	(3,261)					(3,261)
Net Income (Loss)	(144,250)						(144,250)
Ending balance (in shares) at Dec. 31, 2022			126,913,992
Ending balance at Dec. 31, 2022	$ 998,023		$ 127	$ 1,160,882		$ (3,899)	$ (159,087)